I have a 5 year gap in my work history due to depression, should I be upfront about it to employers?

Long story short, I left my previous job (non-programming) amicably but quickly fell into a depression that lasted several years since I couldn't find work. I have since recovered and gotten a master's degree in computer science (3.95 GPA, graduating this December) and several personal projects to fill out my portfolio. I feel like I'm a willing and able employee, just without any job experience. I'm still not sure how much of a red flag that is to employers.

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I was thrown off in a recent interview where the interviewer looked at me skeptically and said "really? 5 years to learn this new field?" and all I could think of was to say "yeah, I self-taught myself a lot during that time".

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Should I reveal that the large break was due to mental health reasons? What if I just left it at "health reasons"? Or is it best to just keep up my story of "I was teaching myself programming and it just took a really long time"?

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edit: the consensus seems to be to keep it under wraps. I'll work on the delivery then. Thank you for the responses!

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