Dealing with a tricky coworker - what got you to quit your job?

I'm currently dealing with a difficult situation with a co-worker in a small office setting. It got me wondering if any of you ever experienced a difficult situation with a co-worker in a small company? How did you handle it? Did you end up leaving the company? If so, what was the last straw? I'd love to hear different perspectives on this as I'm feeling rather conflicted on how to move forward!

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